一種反應(yīng)關(guān)節(jié)組織降解的新型生化指標(biāo)，被設(shè)計(jì)在關(guān)節(jié)炎新型治療方法的臨床試驗(yàn)中使用。

這種免疫分析方法叫做Syncart（helix-II），反應(yīng)尿液中II型膠原的降解片段。II型膠原的降解是反應(yīng)類(lèi)風(fēng)濕關(guān)節(jié)炎與骨軟骨炎時(shí)候軟骨降解的特異指標(biāo)，這是影響了全球15%人口的發(fā)病率很高使人衰弱的關(guān)節(jié)疾病。

2005年4月《關(guān)節(jié)炎和風(fēng)濕》期刊上刊登了這種免疫檢測(cè)方法的詳細(xì)內(nèi)容。這種檢測(cè)方法是由Synarc公司研制開(kāi)發(fā)的，該公司是密集分子指標(biāo)以及藥理學(xué)、生物科技臨床實(shí)驗(yàn)影象檢查的領(lǐng)先服務(wù)供應(yīng)商。

里昂Syncart分子指標(biāo)服務(wù)副總裁兼總經(jīng)理Patrick Garnero博士說(shuō)：“Syncart能夠幫助鑒別早期關(guān)節(jié)炎患者，這些患者處于可能快速進(jìn)展至關(guān)節(jié)病變，因此需要激進(jìn)性結(jié)構(gòu)重建治療。通過(guò)鑒別出用于臨床試驗(yàn)的理想指標(biāo)，這種新型生化指標(biāo)能夠幫助減少研制保全患關(guān)節(jié)炎的關(guān)節(jié)完整性藥物的時(shí)間和成本。”

Biomarker of Cartilage Degradation
 
A novel biochemical marker of joint-tissue breakdown is designed for use in clinical trials of new therapies for arthritis.

The immunoassay, called Syncart (helix-II), shows urinary degradation fragment of type II collagen. The breakdown of type II collagen is a specific indicator of cartilage destruction in rheumatoid arthritis and osteoarthritis, two highly prevalent and debilitating joint diseases collectively afflicting more than 15% of the world’s population.

Details on the immunoassay were provided in the April 2005 issue of Arthritis and Rheumatism. The immunoassay was developed by Synarc, Inc. (Lyon, France), a leading provider of centralized molecular marker and imaging services for clinical trials of the pharmaceutical, biotechnology, and medical devices industries.

“Syncart helps identify early arthritis patients who are at high risk of rapidly progressive joint destruction and therefore in need of aggressive structure-modifying therapy,” explained Patrick Garnero, DSc., Ph.D., vice president and general manager of molecular marker services for Synarc in Lyon. “By identifying ideal candidates for clinical trials, this new biochemical marker helps reduce the time and cost of drug development aimed at preserving joint integrity in arthritis.”