一項(xiàng)最新薈萃分析研究顯示：與其他先進(jìn)得血管緊張素II拮抗劑相比，在降低清晨血壓方面，替米沙坦的效果明顯占據(jù)優(yōu)勢(shì)。

Milano-Bicocca大學(xué)(Italy)的研究人員對(duì)11項(xiàng)臨床研究中5100例輕度－中度高血壓患者的資料進(jìn)行了匯總分析。24小時(shí)動(dòng)態(tài)血壓監(jiān)測(cè)(ABPM)被用于監(jiān)測(cè)血壓下降程度的波動(dòng)，并用于計(jì)算替米沙坦和其他常用抗高血壓藥物的平滑指數(shù)(SI)，包括纈沙坦、洛沙坦、雷米普利和氨氯地平。平滑指數(shù)是預(yù)防器官損傷的有效指標(biāo)，定義為由于治療引起的24小時(shí)血壓變化平均值，除以相應(yīng)的標(biāo)準(zhǔn)差。較高的SI指數(shù)代表血壓下降平穩(wěn)而明顯。
 
Telmisartan Better at Controlling Blood Pressure
  
A new meta-study shows that telmisartan provides superior, powerful blood pressure
reduction from morning to morning compared to other leading angiotensin II blockers.

Researchers from the University of Milano-Bicocca (Italy) examined a pooled analysis of over 5,100 patients with mild-to-moderate hypertension in 11 studies. Ambulatory blood pressure monitoring (ABPM) readings over 24 hours were used to measure fluctuations in blood pressure reductions and to calculate smoothness index (SI) scores for telmisartan and other commonly used antihypertensives, including valsartan, losartan, ramipril, and amlodipine. The smoothness index, a potential indicator for the prevention of organ damage, is defined as the average of the 24 hourly blood pressure changes induced by treatment, divided by the corresponding standard deviation. A high SI score represents a blood pressure reduction that is meaningful and smooth.